Currently the newest of all the atypicals. Abilify has moderate-to-high affinity for a variety of dopamine, as well as serotonin and histamine receptors, thus is well known to be activating, rather than sedating, especially with the bipolar. However that hasn’t stopped Bristol-Myers-Squibb from submitting Abilify to the FDA as a treatment for mania. You’d be better off trying this med in the morning instead of at bedtime like all the other antipsychotics. Best evaluated on a day off, just in case it turns out to be sedating after all, because it does hit serotonin and histamine receptors. In addition to the usual side effects for antipsychotics, Abilify is known for eye twitches and this weird acidic burp that usually goes away.
It hasn’t been on the market long enough for the real freaky side effects to make themselves known, but we were intrigued by reports of intestinal perforation and priapism (the erection that never quits, so who needs Viagra?).
Abilify’s initial dose is 10-15 mg, taken once a day and you should wait at least two weeks before increasing the dose. Abilify has a maximum dosage of 30 mg a day.
Abilify has a half-life of 75 hours.