Buprenex (buprenorphine hyrodchloride). This opiod agoinst-antagonist analgesic has been studied for refractory (i.e. nothing, but nothing will work) depression, especially bipolar depression. And not just the study we have the link for, that’s just the one study that has its data available online. There are other studies as well. Kay Jamison references a couple more in her massive book Manic-Depressive Illness. Mouse had taken it previously for another condition and found that it worked wonders for her depression. Her current psychiatrist has promised to look into it. She’s been taking Suboxone, which has some buprenorphine in it, but unfortunately the naloxone component is notorious for making depression much worse after a few doses, and there are several studies to back up her experience. She needs pure buprenorphine. So don’t be fooled, if you’re going to try the buprenorphine route, do not take Suboxone! Suboxone does have its place as an experimental psychiatric medication, but under other unusual circumstances. As Buprenex is an opioid agoinst-antagonist, it gives you that lovely endorphin warmth as it binds with the opiate receptors favored by morphine. However, as it is also an antagonist it does so without as much of a physical dependence. That’s right, it’s like lesser-addictive morphine. I had previously written “non-addictive” but that’s not the case in the long run, as Mouse has found out from long-term usage. Anything that does opiod agoinism, even with the antagonism built in, will cause a physical dependency. Duh. However, the discontinuation isn’t as bad as from other opiates, although it still sucks. Buprenex is used in detoxification from opiates, although usually Suboxone is used instead, as the depressing naloxone component makes kicking all the easier. Now those of us in bipolar land familiar with the paradoxical reaction to drugs know that opiates frequently make us hypomanic, and that’s where Buprenex comes in as an antidepressant, along with the very old method of using opiates as antidepressants. Antidepressant effects have been noted in both unipolar and bipolar patients in the studies referenced. Because it hits the opiate receptors, Buprenex’s side effects are those common to opiates, mainly nausea, sedation, dizziness, constipation and sweating. Opiates don’t have much in the way of freaky side effects, but you can get bad gas and hallucinate, maybe at the same time like Hunter S. Thompson. In the open-label study of depression the initial dosage used was 0.15mg in the morning and was raised for some patients up to a daily maximum of 1.8mg. So it starts at half the normal dose for pain and can be raised to three times the dose for pain. While the ampules are supplied for intramuscular injection, which means if you do get it you may have to go into a clinic or hospital for daily shots, the study used sublingual drops. I take antigens for my allergies under his tongue instead of by injection, and that works. Buprenex has a mean half-life of 37 hours. No overseas purchase is allowed.