BuSpar (buspirone hydrochloride) The anecdotal evidence amongst people we know who have taken BuSpar is it works fine, as long as you’re taking an antidepressant along with it. By itself it did nothing. But there was a noticeable effect when BuSpar is added to an antidepressant. It doesn’t seem to matter which neurotransmitters are getting messed with, as long as it’s an already working antidepressant. BuSpar blocks the 5HT 1a receptor, which is believed to help block anxiety aggravated by antidepressants. Bristol-Myers-Squibb.