The Upper GI. The upper GI, or gastrointestinal tract, includes the esophagus, the stomach and the upper small intestine (the duodenum). The esophagus carries food from the mouth to the stomach, where food is partially digested. Crohn’s Disease is not as common in the upper GI as it is in the lower small intestine, but can occur. Scarring and narrowing of the esophageal tract due to inflammation may affect swallowing and increase the likelihood of choking. Fistulas, or perforations, can develop in the stomach, which can allow stomach contents to seep into the abdominal cavity itself.

The Small Intestine
Crohn’s Disease occurs most often in the lower small intestine, where the partially digested food from the stomach and upper small intestine undergoes further digestion before being passed into the large intestine.

Crohn's DiseaseIleum
The ileum is the portion of the small intestine that connects it to the large intestine and is the most common location for the condition. Due to its proximity to the appendix, some people mistake the pain of Crohn’s Disease for appendicitis.

The Large Intestine
The large intestine is the end of the digestion process, and the area where feces are formed. It is comprised of the colon and the rectum. The colon finishes the digestive process and forms stools, which are then stored in the rectum. The large intestine, like the ileum, is a common target for the condition.

Skip Areas
Crohn’s may strike different areas of the intestinal tract. For instance, the disease may affect areas of the ileum and the colon, with normal areas between the affected sites. The healthy areas between areas of inflammation are commonly referred to as “skip areas.”

Fibrosis (Scarring)
Chronic inflammation may lead to fibrosis, or the scarring and narrowing of the intestinal tract. Narrowed areas make the possibility of intestinal blockages more likely.

The deep ulcerations caused by the condition may lead to fistulas: abnormal connections or pathways between structures. Should such ulcers penetrate the intestinal walls, intestinal contents may escape into surrounding tissues. Fistulas often occur around the rectum, and can lead to rectal contents seeping into the bladder, the vagina or even through the skin.

The mucosa, muscle, and the serosa are the three layers of the intestinal wall.The Mucosa
The mucosa is the innermost layer of the intestinal wall and lines the intestinal tract. The mucosa absorbs nutrients from digested food.

The middle layer of the intestines is composed of muscle, which contracts rhythmically to push food through the digestive tract.

The outer layer of the intestinal tract is called the serosa. Its outer surface is smooth and slippery and prevents the intestines from sticking to one another and other organs within the abdominal cavity.

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