US Brand Names: Desyrel, Sideril, Trazalon; Trazonil
Other Brand Names: Azonz (Finland)
Beneficat (Argentina)
Bimaran (Argentina)
Deprax (Spain)
Depresil (Philippines)Depyrel (Israel)
Desirel (Thailand)
Mesyrel (Taiwan)
Manegan (Argentina)
Molipaxin (United Kingdom; Ireland; South Africa)
Pragmarel (France)
Reslin (Japan)
Taxagon (Argentina)
Thombran (Germany)
Trazolan (Belgium; India; Netherlands)
Trazone (Indonesia; Portugal; Taiwan)
Trittico (Austria; Colombia; Greece; Hong Kong; Italy; Peru; Switzerland)
トラゾドン / Torazodon (Japan)
טריטיקו / Trittico (Israel)
טרזודיל 100 / Trazodil 100 (Israel)
Other Forms: orange flavored solution
Generic Name: trazodone
What is Desyrel (trazodone): Desyrel (trazodone) is an Antidepressant. Specifically a phenylpiperazine.
Read up on these sections if you haven’t done so already, because they cover a lot of information about multiple medications that I’m not going to repeat on many pages. I’m just autistic that way about not repeating myself.
What FDA is the Approved Use of Desyrel (trazodone): Desyrel (trazodone) is approved to treat major depressive disorder, with or without anxiety.
What are Some of the Off-Label Uses of Desyrel (trazodone): Desyrel (trazodone) is also prescribed to treat:
Sleep Disorders
Bipolar Depression
Chronic Fatigue
Irritable Bowel Syndrome
Eating Disorders

Desyrel’s (trazodone’s) pros and cons:
Pros: The antidepressant you need if you have the combination of insomnia combined with mild depression and/or anxiety. One of the few, if any, antidepressants and/or sleep medications on the market that is not addictive / habit forming.
Cons: You might just sleep a little too well.
Desyrel’s (trazodone’s) Typical Side Effects: – sleepiness, headache, sleepiness, dizziness, sleepiness, nausea, sleepiness, dry mouth, sleepiness, blurry vision, sleepiness, sweating, sleepiness, insomnia or sleepiness, diarrhea or constipation, and did I mention you’ll be tired? Most everything but the sleepiness and, if you get the, dizziness and blurry vision, will go away within a week or two. The dizziness and blurry vision may take a little longer. If they last too long, talk to your doctor.

Desyrel’s (trazodone’s) Not So Common Side Effects: Low blood pressure, weight gain. General cardiac weirdness, so Desyrel shouldn’t be used if you have a history or family history of heart issues, at least, not without prior clearance from a cardiologist. Since it makes you sleep better, many people report vivid or unusual dreams. Like Seroquel, another medication prescribed for insomnia alone, there’s sometimes a nasty hangover the first few days after using Desyrel. It usually goes away in a day or two.

These may or may not happen to you don’t, so don’t be surprised one way or the other.

Desyrel’s (trazodone’s) Freaky Rare Side Effects: Priapism so bad that surgical intervention was required to get rid of the unending hard-on. Bob Dole shouldn’t have relied on Viagra to take on Bill Clinton, Bob Dole should have tried Desyrel (trazodone) to go mano a mano with the president. Wait, there’s more. Not only can men get stuck that way, but women too, as it once caused clitoral priapism.

You aren’t going to get these. I promise.

Interesting Stuff Your Doctor Probably Won’t Tell You: Desyrel (trazodone) is best taken with food, so take it after dinner, or dessert, to ensure a quality night’s rest.

Desyrel’s (trazodone’s) Dosage and How to Take Desyrel (trazodone): The initial dose is 150mg a night, taken after dinner or “a light snack.” But, really, start at just 50mg if you want to wake up the next morning. If you don’t respond after one week, increase it to 100mg. Unlike SSRIs, people respond to Desyrel rather quickly, so you can work up to that 150mg dosage after two weeks, then wait a month before increasing the dosage. After that it’s an increase of 50mg a day every four days or so, dividing the dosage, until you reach the maximum of 400mg a day.

Days to Reach a Steady State: Steady state data weren’t published, probably due to its having a double metabolism with an active metabolite.

When you’re fully saturated with the medication and less prone to peaks and valleys of effects. You still might have peaks of effect after taking many meds, but with a lot of the meds you’ll have fewer valleys after this point. In theory anyway.

How Long Desyrel (trazodone) Takes to Work: Unlike most reuptake inhibitors, Desyrel works for 75% of people within two weeks. If it’s going to work at all, that is. Give it a month, of course.

Desyrel’s (trazodone’s) Half-Life: Desyrel (trazodone) has a double metabolism. The half-life for trazodone is 3 to 6 hours, while the half-life for its metabolite is 5 to 9 hours. Apothecon didn’t publish an aggregate, so maybe at least 15 hours total.

Average Time for Desyrel (trazodone) to Clear Out of Your System: I’m guessing three days to clear out of your system.

How to Stop Taking Desyrel (trazodone): Your doctor should be recommending that you reduce your dosage by 50-100mg a day every 3-5 days if you need to stop taking Desyrel (trazodone). Based on the combined 8-15 hour half-lives. As Desyrel (trazodone) is non-addictive / not habit forming, if you have to stop taking it at a faster rate, you’ll probably be OK. For more information, please see the page on how to safely stop taking these crazy meds.
If you’ve worked your way up to a particular dosage, it’s usually best to spend this many days at the next lowest dosage before going down the next lowest dosage before that and so forth. This is the least sucky way to avoid problems when stopping any psychiatric medication. Presuming you have the option of slowly tapering off them.

Comments: Desyrel (trazodone) is the official antidepressant of Sleepy-bye Land. It is rarely prescribed as monotherapy these days. Hell, Desyrel is rarely prescribed at all, the generic trazodone is what is in all those bottles. It’s mostly an add-on antidepressant in case you have insomnia combined with your depression and/or anxiety. If you respond well to SSRIs and you’re not sleeping or are otherwise agitated, trazodone is a good addition to your cocktail to make sure you sleep. And sleep. And sleep. If you’re going for the combination of antipsychotic and antidepressant, don’t mix Desyrel (trazodone) with Seroquel if you want to wake up any time this week. We’ve come across one person actually taking this combination and she has one hell of a time getting up every morning.

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