One of the newer atypicals, Geodon is proving to be effective in helping with bipolar depression, as it hits a lot of dopamine receptors and does a bit of serotonin and norepinephrine reuptake inhibition. Its side effect profile is pretty low and it’s generally weight neutral. Reads like a winner, right? Well, if you really want to play it safe you should get an EKG before taking Geodon, because there’s a nice sudden death warning for prolonged QT intervals. We don’t know what the hell a QT interval is, as that’s cardiac language. All we do know is that Geodon can mess with your heart and if you have a history of heart troubles, Geodon may not be for you. This is where you’d need your cardiologist and psychiatrist talking to each other, and where getting all your health services from an HMO is an advantage because it would be easier for them to talk to each other when they all work for the same HMO. As for our experience with it, Geodon eliminated Mouse’s short-term memory. The real short-term memory of the previous seven seconds. She couldn’t remember what she had said, what she had put in her pocket, anything like that. Plus it made her manic as hell, and mania is a fairly common thing to watch out for amongst the bipolar, most likely due to the serotonin and norepinephrine reuptake inhibition. She was living in a fantasy world of a multimillion-dollar lawsuit against Pfizer over Geodon, and spent the money she would be winning. Anecdotal evidence is piling up that Geodon can aggravate, or even induce mania in bipolar, especially when combined with an antidepressant or the more antidepressing of the mood stabilizers like lithium or Lamictal, so use with caution in bipolar where mania is a problem.
Freakiest rare side effects: bed wetting, involuntary rotating of the eyes.
Geodon’s initial dose is 20 mg twice a day taken with food. The dose may be increased every two to three days to the maximum dose of 160 mg a day taken in two 80-mg doses with breakfast and dinner, but that’s a pretty rapid titration and is based on severe cases of in-patient schizophrenia and Geodon’s short half-life. For other ailments you could probably increase the dose weekly, if required.
Geodon has a half-life of 7 hours.