Ketoconazole is an antifungal imidazole derivative whose presentation includes shampoo, topical cream or tablet or tablets.
Ketoconazole is an antifungal medicine that prevents the growth of fungi that cause infection. Ketoconazole is used both topically and systemically. Used topically shown effective in combating the fitodermatosis of the skin, nails or hair, in candidiasis of the mouth , esophagus and chronic mucocutaneous, like for vulvovaginitis, also caused by Candida. As used shampoo to fight dandruff, particularly against the fungus pitirosporum ovale , which is credited with this type of dermatosis of the scalp. By the systemic route is useful in the treatment of blastomycosis, coccidioidomycosis, paracoccidioidomycosis and histoplasmosis.
Dosage of ketoconazole
We suggest taking ketoconazole with meals. The prescribed dosage will vary depending on what the infection being treated and the severity thereof. As a guide the dose may be:
¤ With respect to the cream, in cases of cutaneous candidiasis, apply to the affected area once daily for 2 weeks.
¤ When it is seborrheic dermatitis application is 2 times daily for a period of 4 weeks.
¤ The shampoo should be applied 2 times per week for a period of 4 weeks.
¤ The tablets, in adults, will be administered in doses of 200 mg. per day. When infections are of greater severity may be double the dose. With regard to children (from 2 years old) were administered a single dose of 3.3 mg. per kg. weight can increase to 6.6 mg. per kg. weight.
Or adverse side effects of ketoconazole
The most common symptoms associated with the use of ketoconazole are:
¤ Nausea or vomiting.
¤ Abdominal pain.
¤ Thrombocytopenia .
¤ Hemolytic anemia .
With ketoconazole shampoo reactions may occur in the hair, as a fall or changes in texture. They may also appear pustules, dryness or itching. With the use of the tablets have been few cases of hepatotoxicity, although only 1 in 10,000 exposed patients. Orally have also appreciated some cases of anaphylaxis and hypersensitivity reactions, but rarely provided. The excessive and prolonged use of ketoconazole is likely to result in decreased testosterone levels. In some people have appeared certain neuropsychiatric disorders in nature, including severe depression and even suicidal. Once again, ie it is highly unusual symptoms.
Contraindication of ketoconazole
Ketoconazole should not be administered in combination with drugs such as astemizole, cisapride, terfenadine or drugs containing terfenadine, as could be significantly increased risks affecting the heart. When on antacids, cimetidine, famotidine, omeprazole or ranitidine while ketoconazole is administered, they must be at least 2 hours after ketoconazole, since otherwise the effects of ketoconazole would not be desirable. As with many medications, you should not be ingested alcohol while taking this drug, even one day after the prescription has been completed it.
Ketoconazole and pregnancy and lactation
When absorption is not topical or no contraindications for pregnancy or in lactation, however, when his administration is not suitable for oral use in pregnant or nursing women, since the experimentation carried out on animals, particularly rats, has shown that alterations can occur in the fetus.