Health QuestionsCategory: TreatmentsAbstract:  30% risk of hyponatremia
gretl asked 3 years ago

Quote:

Hyponatremia from oxcarbazepine and carbamazepine.
Dong X, Leppik IE, White J, Rarick J.
Department of Neurology, University of Minnesota, Minneapolis, MN 55455, USA. dongx015@umn.edu
The authors examined sodium concentrations from 97 oxcarbazepine-treated (OXC) and 451 carbamazepine-treated (CBZ) patients with epilepsy using cross-section and follow-up studies. The frequency of hyponatremia (Na+ < or = 134 mEq/L) was 29.9% among OXC-treated patients and 13.5% among CBZ-treated patients (p < 0.0001). Hyponatremia (Na+ < or = 128 mEq/L) was severe: 12.4% of OXC-treated patients and 2.8% of CBZ-treated patients (p < 0.001). Advanced age was a risk factor for hyponatremia. Hyponatremia, once present, persisted in both groups.
Neurology. 2005 Dec 27;65(12):1976-8.
Source: Pubmed abstract

Just a reminder to monitor sodium levels while on Trileptal (and, to a lesser extent, Tegetrol.)  Mine dipped to 121 at one point, triggering seizures … with careful attention and changes in other meds, I was able to keep it around 133 (normal is ~135-145) for a couple of years but gave in recently and switched to Lamictal.  I had my electrolytes tested last week and my sodium was 141.  Yay!  (Yes, that’s an odd thing to cheer about.)

5 Answers
mania answered 3 years ago

Re: Abstract:  30% risk of hyponatremia
With Lamictal out of my picture, Trileptal is looking less and less attractive.
 
 
m

gretl answered 3 years ago

Re: Abstract:  30% risk of hyponatremia
Well … I don’t want to scare people away from it.  There’s a reason I stuck with it so long; it worked for me.  My daughter’s been on it for almost 4 years now, and never had problems.  But the sodium thing is definitely one more factor to consider.

StrungOutOnLife answered 3 years ago

Re: Abstract:  30% risk of hyponatremia
I’m pinning it because someone’s going to want to know and this could get buried.

damnmeds77 answered 3 years ago

Re: Abstract:  30% risk of hyponatremia
That’s interesting, i never knew that sodium had anything to do with trileptal.  i have to find my last gen. check up and see if my sodium levels are normal, just out of curiosity.  i haven’t had any problems and am not at a high dose.  I don’t know, why not check it just to see.

gretl answered 3 years ago

Re: Abstract:  30% risk of hyponatremia

Well, looking at the laundry list in your sig, I’d definitely recommend checking your sodium levels.  Constant borderline hyponatremia was *one* factor in my own chronic fatigue type symptoms.

gretl asked 3 years ago

Quote:

Hyponatremia from oxcarbazepine and carbamazepine.
Dong X, Leppik IE, White J, Rarick J.
Department of Neurology, University of Minnesota, Minneapolis, MN 55455, USA. dongx015@umn.edu
The authors examined sodium concentrations from 97 oxcarbazepine-treated (OXC) and 451 carbamazepine-treated (CBZ) patients with epilepsy using cross-section and follow-up studies. The frequency of hyponatremia (Na+ < or = 134 mEq/L) was 29.9% among OXC-treated patients and 13.5% among CBZ-treated patients (p < 0.0001). Hyponatremia (Na+ < or = 128 mEq/L) was severe: 12.4% of OXC-treated patients and 2.8% of CBZ-treated patients (p < 0.001). Advanced age was a risk factor for hyponatremia. Hyponatremia, once present, persisted in both groups.
Neurology. 2005 Dec 27;65(12):1976-8.
Source: Pubmed abstract

Just a reminder to monitor sodium levels while on Trileptal (and, to a lesser extent, Tegetrol.)  Mine dipped to 121 at one point, triggering seizures … with careful attention and changes in other meds, I was able to keep it around 133 (normal is ~135-145) for a couple of years but gave in recently and switched to Lamictal.  I had my electrolytes tested last week and my sodium was 141.  Yay!  (Yes, that’s an odd thing to cheer about.)

3 Answers
mania answered 3 years ago

Re: Abstract:  30% risk of hyponatremia
With Lamictal out of my picture, Trileptal is looking less and less attractive.
 
 
m

gretl answered 3 years ago

Re: Abstract:  30% risk of hyponatremia
Well … I don’t want to scare people away from it.  There’s a reason I stuck with it so long; it worked for me.  My daughter’s been on it for almost 4 years now, and never had problems.  But the sodium thing is definitely one more factor to consider.

StrungOutOnLife answered 3 years ago

Re: Abstract:  30% risk of hyponatremia
I’m pinning it because someone’s going to want to know and this could get buried.

damnmeds77 answered 3 years ago

Re: Abstract:  30% risk of hyponatremia
That’s interesting, i never knew that sodium had anything to do with trileptal.  i have to find my last gen. check up and see if my sodium levels are normal, just out of curiosity.  i haven’t had any problems and am not at a high dose.  I don’t know, why not check it just to see.

gretl answered 3 years ago

Re: Abstract:  30% risk of hyponatremia

Well, looking at the laundry list in your sig, I’d definitely recommend checking your sodium levels.  Constant borderline hyponatremia was *one* factor in my own chronic fatigue type symptoms.

gretl asked 3 years ago

Quote:

Hyponatremia from oxcarbazepine and carbamazepine.
Dong X, Leppik IE, White J, Rarick J.
Department of Neurology, University of Minnesota, Minneapolis, MN 55455, USA. dongx015@umn.edu
The authors examined sodium concentrations from 97 oxcarbazepine-treated (OXC) and 451 carbamazepine-treated (CBZ) patients with epilepsy using cross-section and follow-up studies. The frequency of hyponatremia (Na+ < or = 134 mEq/L) was 29.9% among OXC-treated patients and 13.5% among CBZ-treated patients (p < 0.0001). Hyponatremia (Na+ < or = 128 mEq/L) was severe: 12.4% of OXC-treated patients and 2.8% of CBZ-treated patients (p < 0.001). Advanced age was a risk factor for hyponatremia. Hyponatremia, once present, persisted in both groups.
Neurology. 2005 Dec 27;65(12):1976-8.
Source: Pubmed abstract

Just a reminder to monitor sodium levels while on Trileptal (and, to a lesser extent, Tegetrol.)  Mine dipped to 121 at one point, triggering seizures … with careful attention and changes in other meds, I was able to keep it around 133 (normal is ~135-145) for a couple of years but gave in recently and switched to Lamictal.  I had my electrolytes tested last week and my sodium was 141.  Yay!  (Yes, that’s an odd thing to cheer about.)

5 Answers
mania answered 3 years ago

Re: Abstract:  30% risk of hyponatremia
With Lamictal out of my picture, Trileptal is looking less and less attractive.
 
 
m

gretl answered 3 years ago

Re: Abstract:  30% risk of hyponatremia
Well … I don’t want to scare people away from it.  There’s a reason I stuck with it so long; it worked for me.  My daughter’s been on it for almost 4 years now, and never had problems.  But the sodium thing is definitely one more factor to consider.

StrungOutOnLife answered 3 years ago

Re: Abstract:  30% risk of hyponatremia
I’m pinning it because someone’s going to want to know and this could get buried.

damnmeds77 answered 3 years ago

Re: Abstract:  30% risk of hyponatremia
That’s interesting, i never knew that sodium had anything to do with trileptal.  i have to find my last gen. check up and see if my sodium levels are normal, just out of curiosity.  i haven’t had any problems and am not at a high dose.  I don’t know, why not check it just to see.

gretl answered 3 years ago

Re: Abstract:  30% risk of hyponatremia

Well, looking at the laundry list in your sig, I’d definitely recommend checking your sodium levels.  Constant borderline hyponatremia was *one* factor in my own chronic fatigue type symptoms.