Health QuestionsCategory: MedicationsHerbals for increase in GABA
daikomeo asked 2 years ago

Does anyone or has anyone heard of or know of any herbal supplements for Benzodiazapines (which help with the GABA neurotransmitter “transmission” between the neurons?
I’m looking for an altnerative way of dealing with my “unexplainable” anxiety that I have without the anti-anxiety medication.
Let me know if you all have found anything that works.

6 Answers
swingingfast answered 2 years ago

I went to a herb store after i had my made spell from taking Provigil and the man could see how shacken up i was and he gave me SEREDYN  to try maybe it will work for you!

Gary replied 2 years ago

Valerian. It feels like Valium to me. (Kava kava is another herbal sedative, but I think it has been withdrawn from the market due to reports of acute liver failure.)

Ian answered 2 years ago

While many have claimed they’ve produced an active form of GABA that can penetrate the Blood Brain barrrier,  is highly unlikely. Certainly, none of the drug companies have been able to without it loosing the ability to interact with GABA receptors.  
There is a very good reason why none of the neurotransmitters can enter the brain, if they could then the brain would be hostage to the stomach. That would be especially important with an amino acid like GABA which is found in most foods.

Ian answered 2 years ago

Its is also unlikely, indeed impossible, to be deficient in GABA. Brains generally have about 1,000 times more of it than any of the monoamine neurotransmitters like serotonin.
GABA is produced in the brain as a by product of the brain’s fuel cycle (Krebs cycle) in which glucose (sugar) is the primary precursor. Your brain would stop functioning due to energy depletion long before GABA levels dropped to the point that it became a problem.
If you have either epilepsy or an anxiety disorder then you probably have fewer GABA receptors than “normal” but that can’t be overcome by increasing the already abundant quantities of GABA anymore than adding more gas to the tank will fix a car engine missing half its sparkplugs.
BTW – while gabapentin (Neurontin) is an analogue of GABA (its GABA with an added pentin ring) it works on the brain’s glutamate system and has no effect on GABA receptors nor does it alter GABA uptake or degradation. Neither does the latest GABA analogue, pregabalin.
Interestingly, none of these analogues seem to be metabolized, but are excreted unchanged in the urine.

Kassiane replied 2 years ago

Tell this to the docs who dx’d me. And tell this to my brain the next time something sends me batshit, mkay? Because clearly my so called GABA didn’t get the memo.

failed more anticonvulsants than most people can name

Kassiane answered 2 years ago

Bet. me.
I am paradoxical on anything that ‘decreases GABA reuptake’ for a reason. At least 4 doctors have said a GABA deficiency is the most likely explaination.

Kassiane answered 2 years ago

Oh. Wait. That krebs cycle thing with the mitochondria??? That one??
Leigh’s Syndrome.
For starters….