Health QuestionsCategory: MedicationsKeppra Rage – I hope.
am_dragon asked 3 years ago

Hello, I just wanted to post my experience with Keppra, I hope this is the correct place for this post.  I’m a 36 year old male, I also have a liver disorder (PSC – Primary Sclerosing Cholangitis) and Ulcerative Colitis.  
 
I was diagnosed with partial complex seizure disorder about 2 years ago.  I know now that I’ve had seizures for the last 15 years at least, but very infrequently.  I started to have seizures almost every night before I went to bed and went to the Doctor.  First I was given Neurontin… I didn’t get out of bed for 2 weeks.  I was very fatigued and tired all the time.  I quit taking it, had 40 seizures in 1 day, ended up in the ER and was given Lamictal.
 
Lamictal, again made me very tired and I didn’t really care.  My wife was dragging me to work.  She called the Dr. to get the meds changed again.
 
June ’05 I started taking Keppra. 2000MG / day.
 
After a few uncontrollable raging fits, and feeling depressed I started talking to a counselor in Jan ’06.  He said I should take a vacation, relax, normal anger management stuff.  At this point I was convinced my frustration was due to a job change, new house, our kids.  
 
I work on controlling my anger but it is there all the time.  I am frustrated at nothing and everything at the same time.  I try to rationalize my anger but I can’t put my finger on why I’m mad.  Sometimes I can talk myself out of the anger only to have some minor thing happen (like someone asking me for help at work) and I’m 100% ticked off again.  I also have a really hard time making decisions.  I tend to pace the house because I don’t know what I want to do, and I’m not satisfied doing anything.  I’ll drive around town for an hour at lunch, with $3.00/gallon gas trying to decide what to eat.  I have a really hard time focusing on work.  I use to workout every day, now I’m lucky if it workout 3x per week, and that frustrates me too.
 
Early July ’06, raging fit of anger, couldn’t calm down, paced the floor until 3am.  I fell asleep and woke up at 6am with the worst headache in the world.  Took two rounds of pain killers to knock it out and the ER recommended I see my neurologist.  
 
Aug ’06 – My birthday actually, raging fit over nothing, punched 2 holes in the wall, screaming in front of my kids, told my wife I hated her, threatened suicide, left the house.  My wife got a call from the neurologist (about the headache above, lucky coincidence may have saved my marriage) and asked if the medicine I was on could make me angry.  The nurse said “yes”.  My wife did some research and told me when I got home.  I saw the Dr. the next day and I’m changing to Carbatrol.
 
I did not know about the anger side effect of Keppra.  I just wanted to post this in case someone else didn’t know.  I may update this in a month once I’m weened off the Keppra.

12 Answers
StrungOutOnLife answered 3 years ago

Re: Keppra Rage – I hope.
How many times a day are you taking it? Kassiane found that she had to take it four times a day instead of two, because of Keppra rebound rage.
 
ETA: The second half of your post doesn’t quite sound like that. Hers was just as she was about to take the next dose. Yours lasted too long.

am_dragon answered 3 years ago

Re: Keppra Rage – I hope.
I read the “rebound theory” on one of the Keppra pages.  I take 2 500MG pills twice a day.  When I get up and just before bed, usually at about 7am and 9pm.  I’ve tried to put a time on my outbursts, but most were right after I would have taken a dose.  Not to mention I am depressed all the time.  I can’t focus on work and don’t want to go.  Actually I thought I was in some kind of deep depression and couldn’t figure out why.  I think 6 months ago I would have spread out the dosage to see if that helped.  Now I’ve got to get off this stuff before I do something I can’t fix…
 
Thanks for the advice though.

StrungOutOnLife answered 3 years ago

Re: Keppra Rage – I hope.
Quote from am_dragon on 12. Aug 2006 at 07:29:

I read the “rebound theory” on one of the Keppra pages. I take 2 500MG pills twice a day. When I get up and just before bed, usually at about 7am and 9pm. I’ve tried to put a time on my outbursts, but most were right after I would have taken a dose. Not to mention I am depressed all the time. I can’t focus on work and don’t want to go. Actually I thought I was in some kind of deep depression and couldn’t figure out why. I think 6 months ago I would have spread out the dosage to see if that helped. Now I’ve got to get off this stuff before I do something I can’t fix…

Thanks for the advice though.

Thanks for clarifying.

Kassiane answered 3 years ago

Re: Keppra Rage – I hope.
Quote from am_dragon on 12. Aug 2006 at 07:29:

I read the “rebound theory” on one of the Keppra pages.  I take 2 500MG pills twice a day.  When I get up and just before bed, usually at about 7am and 9pm.  I’ve tried to put a time on my outbursts, but most were right after I would have taken a dose.

 
So 14 hours apart.
The half life of Keppra is around 8 hours. Rebound theory still might apply, at least for the anger/
 
  Quote:

Not to mention I am depressed all the time.  I can’t focus on work and don’t want to go.  Actually I thought I was in some kind of deep depression and couldn’t figure out why.  I think 6 months ago I would have spread out the dosage to see if that helped.  Now I’ve got to get off this stuff before I do something I can’t fix…
.

 
Another stupid question: Have you been exercising? Theres some anecdotal evidence that exercise really decreases the depression factor.
 
Exposure to too many ACs leaves one open to developing drug resistance. And intractability SUCKS. It could be a dose thing, or something else, or being depressed because epilepsy does that. I’d bring THOSE up before d/cing a med that works. But then, I rarely have meds that work.
 
Kassiane

seaweed answered 3 years ago

Re: Keppra Rage – I hope.
keppra doesn’t make my rage issues worse, but i do get VERY depressed if i take my doses too close together.  i take 625mg/day, spread out over 4 doses (125mg, 250mg, 125mg, 125mg).  if i don’t have at least 5 – 5 1/2  hours between doses, i pretty much end up wanting to kill myself for a least a day or two.  
 
if you end up wanting to retry keppra, i’d suggest at least TIB or QID dosing.  although the PI sheet says steady state is acheived with twice daily dosing, since the half-life is 6-8 hours, i think a minimum of 3 doses a day is best.  with that, you’d probably have more luck avoiding the depression & rage, too.