Health QuestionsCategory: MedicationsKlonopin versus Clonazepam
apexegg asked 2 years ago

I’ve read that brand name Klonopin is much more effective than the generic Clonazepam, and wanted to know if anyone has noticed a noticable difference. Right now i’m on the generic, but if it’s worth it, i wouldnt have a problem switching to brand name Klonopin, in fact, i might even be a bit more comfortable with it. Also, can psych’s request that i get the brand name prescription, or is it completely up to the insurance company? And, if so, under what circumstances would the doctor specify that i need the brand name Klonopin? Thanks.

4 Answers
blueyez answered 2 years ago

Re: Klonopin versus Clonazepam
I suffer from severe anxiety and paranoiya and honestly……i have taken both and not noticed the difference….maybe its the way ppl metabolize them….

mania answered 2 years ago

Re: Klonopin versus Clonazepam
Quote from apexegg on 23. Jan 2006 at 18:15:

I’ve read that brand name Klonopin is much more effective than the generic Clonazepam, and wanted to know if anyone has noticed a noticable difference. Right now i’m on the generic, but if it’s worth it, i wouldnt have a problem switching to brand name Klonopin, in fact, i might even be a bit more comfortable with it. Also, can psych’s request that i get the brand name prescription, or is it completely up to the insurance company? And, if so, under what circumstances would the doctor specify that i need the brand name Klonopin? Thanks.

 
Here is the short answer from the Merck Manual:
 
“Legally, bioequivalence of different versions of a drug can vary by up to 20%, because for most drugs, such variation does not noticeably alter effectiveness or safety. However, actual differences between FDA-approved generic and trade-name drugs are generally much smaller than the allowable 20%. Actual differences are typically only about 3.5% on average and rarely exceed 10% in any single study of bioequivalence.”
 
i.e. No, they’re not the same.  But you may not be able to tell the difference depending on your own mental and physical make-up (some people don’t/can’t).  Or you will be able to tell the difference and will feel better not worse.
 
With some drugs, e.g. Lithium, and others that require precise blood level monitoring, switching from a trade name to a generic or vice versa is downright dangerous due not only to the bioequivalence factor, but also the variance in inactive ingredients (which can be a problem whenever one switches drugs).
 
Issues in bioequivalence (deals with heart meds, but has great overall info):
http://www.americanheart.org/presenter.jhtml?identifier=3015266
 
The (all but useless) FDA office of Generic Drugs:
http://www.accessdata.fda.gov/scripts/cder/iig/index.cfm
 
And, the Requisite “Study from a Medical Journal”:
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&lis
t_uids=12860486&dopt=Citation
 
Yes, your doc can write “Label Only”.  Your insurance can argue with you, but if you’re willing to pay the higher copay or whatever, and your doc does the medical necessity (if your insurance takes it that far – most don’t), you’ll get brand name.
 
I’ve only received brand name Klono once, and yes, it did work better for me.  But I’m on Army insurance, so the fight involved to get Label only just isn’t worth it.  Pick your battles and all…
 
 
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antipeople answered 2 years ago

Re: Klonopin versus Clonazepam
Personally,  I confirmed my suspicions about how much stronger brand-name Klonopin is compared to the generic yesterday. Generic clonzepam just makes me a little less anxious, and generally doesn’t do much for me. Brand name Klonopin, on the other hand, feels like a fucking horse tranquilizer and I basically have to work really hard to stay awake for the first hour or so after I take it, and I’m wobbly, can’t walk very well, certainly can’t drive, and even have trouble talking. However, after that wears off, my anxiety is completely gone for the next 6-7 hours or more.
 
Yeah. The pharmacist that told me there’s no difference between generic and brand name is full of shit. Smiley

jookeyman answered 2 years ago

Re: Klonopin versus Clonazepam
I was first prescribed clonazepam about three years ago and it seemed to work o.k. Then one day I got my script refilled and the color of the pills was different but the dose was the same. I called the pharmacy to check on this and they told me that it was made by a different manufacturer than my old script. I didn’t think it was a big deal at the time until I noticed they didn’t work! Damned placebo. I’ve been buying name brand Klonopin ever since and I have had no problem with consistent effect.
 
BTW-read Jerod’s writeup on Brand vs. generic, especially the part about clonazepam.