Health QuestionsCategory: TreatmentsNightmares and sleep meds.
martasi asked 3 years ago

Need feedback on which sleep meds have worked for you w/o causing nightmares. I can’t sleep at all w/o medication but Ambien, Klonopin and Lunesta cause terrible nightmares. Sonata doesn’t work, Ativan and Xanax leave me with bad morning depression and fatigue.
 
Yes, I’m working with my PDoc on this but would appreciate hearing from others about what works for them.  FYI, I take Lithium at night so that’s in the mix already.
 

9 Answers
lynnieg answered 3 years ago

Re: Nightmares and sleep meds.
One word:  SEROQUEL.
 
Only takes 25-50 mgs (for me), but my doc says I can take up to 100 (NOT!  I’ll sleep a week).  And I sleep like a baby.  No unpleasant lights-out sleep like Ambien or Lunesta gives you–y’know, it’s like you just get knocked over the head–you get pleasantly sleepy and drift off.  At least I do.  And I do dream, but I’ve never had a nightmare on it. A couple of silly dreams, but they made me laugh the next day.

Kassiane answered 3 years ago

Re: Nightmares and sleep meds.
Rozerem didn’t give me nightmares.
 
But it did give me a rather long panic attack every time i took it, and then once that was over, thunk, out cold. At least for a week
 
NOTHING puts me to sleep for very long, right now it’s 2 flexeril and that works half the time. I take this with benadryl, and 2mg klonopin that I’m trying to get off because tolerance=more seizures and that’s stupid.
 
Kassiane

KatD answered 3 years ago

Re: Nightmares and sleep meds.
Kassianne-(or anyone else)
 
Do you happen to know the mechanism of action for flexeril?  What neurotransmitters does it hit?
 
I read somewhere that it acts similar to a tricyclic but how so.  I have been googling like crazy but can’t find this specific info.
 
Just to be clear the type of information I’m looking for, I’m going to list two examples of drugs I do know the mechanism of action for below.  
 
amitriptyline:
  dibenzocycloheptadiene:
tertiary TCA
NE reuptake inhibition ++
5-HT reuptake inhibition ++
5-HT2 antagonist ++
ACh antagonist
H1 antagonist
NE-alpha1 antagonist  
 
 
Remeron:
 piperazinoazepine:
NE-alpha2 antagonist
5-HT2a antagonist ++
5-HT2c antagonist
5-HT3 antagonist
H1 antagonist  
 
So, just to be clear, I don’t need infor on amitryptiline or remeron but I would like the above TYPE of information on flexeril.
 
thanks for any input! K
 

mania answered 3 years ago

Re: Nightmares and sleep meds.
Flexeril, per RxList: Pharmacological studies in animals showed a similarity between the effects of cyclobenzaprine and the structurally related tricyclic antidepressants, including reserpine antagonism, norepinephrine potentiation, potent peripheral and central anticholinergic effects, and sedation.  
 
reserpine:
A chemically pure derivative of the plant Rauwolfia serpentina. It lowers blood pressure and acts as a tranquilizer.
 
norepinephrine:
1. A hormone produced by the adrenal medulla, similar in chemical and pharmacological properties to epinephrine, but chiefly a vasoconstrictor with little effect on cardiac output. 2. A neurotransmitter released by most sympathetic postganglionic neurons and by some neurons of the brain.
 
anticholinergic:
1. Impeding the impulses of cholinergic, esp. parasympathetic, nerve fibers. 2. An agent that blocks parasympathetic nerve impulses. The side effects, which include dry mouth and blurred vision, are seen in phenothiazine and tricyclic antidepressant drug therapy. SYN: parasympatholytic.
 
Source: Taber’s Cyclopedic Medical Dictionary,” Copyright © 2005 by F. A. Davis Co., Phil., PA, via RxList
 
 
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KatD answered 3 years ago

Re: Nightmares and sleep meds.
Thanks so much Mania.  I can’t believe it works on norepenephrine!  I tend not to do well on anything that works on that particular neurotransmitter!
 
I wonder if it has a withdrawal syndrome like the TCA’s?