Health QuestionsSSRI and Clorazapate
paxil180 asked 2 years ago

Hi, I’m a depressed guy who has to take an SSRI everyday to feel ok. I’m ok with that. In fact my paxil and Zoloft sometimes make me feel so good I think I feel better than normal people who aren’t depressed and don’t take any crazymeds. Maybe. My question is about a Benzo – specifically Clorazapate.
  Will I suffer any long term effects from taking a daily 7.5mg dose of Clorazapate (or the equivilant 5mg dose of valium) to go along with my 150mg zoloft? I don’t ask a doctor because as most of you know these Benzos are for sale on practically every street corner in America, getting them isn’t a problem.

10 Answers
asery answered 2 years ago

It’s not unusual for a benzo to be added to an SSRI if you’re at the maximum tolerable dose of the SSRI and still having residual or situational anxiety.  Or (as in your case) while you’re giving the Zoloft time to take full effect.
 
But it’s not smart to keep things from your pdoc.  He needs full information to properly treat you, and if he’s doing that, you shouldn’t have to be buying things on street corners in addition to the neighborhood pharmacy!

mania answered 2 years ago

Yes, and no.
 
If you are on the depressed end of the scale, a benzo is the last drug you want to be tossing back, unless you have been Rx’d it for a comorbid anxiety condition. Which you obviously haven’t, or you’d be asking your doctor this, and wouldn’t be considering purchasing it on a street corner in HCM city.  (Although, if you had been Dx’d with panic, it says Here that Zoloft actually works just fine all by itself. )  
 
CNS depression, a really easy slide into addiction, an even harder fight out of said addiction, short half-lives, an ever increasing dose… the list goes on and on; is this something you want to take on if you don’t have to?
 
On to pharmacology.  They are both metabolized by your liver (Zoloft, also by kidneys).  Is your liver in good shape?  How about all of the nasty side effects and general “wrong” reasons for taking them in the first place?  See Here for Jerod’s lovely take on life, the universe, and everything you ever wanted to know about benzo use and abuse.  “In the bipolar world, there is a downside to long-term use of benzos. Their long-term use aggravates depression, especially bipolar depression, which is just one more reason why they are not a good class of drugs for control of mania in of themselves.” ( (c.) Jerod Poore)

Mag12 answered 2 years ago

“It’s amazing how much panic one honest man can spread among a multitude of hypocrites.”

– Thomas Sowell

“Nightmares, daymares, sneak-up-behind-you-and-kick-you-in-the-butt-mares… “

— Haunted_leaves, on manic/mixed episodes

They dont give me the charcoal, they tell me about Rasputin.

— Ragemaxis

panic-11 answered 2 years ago

Dude you must be confusing me with someone else’s posts on the board. My deal oficially is the Major Depressive Disorder. Frankly, it’s because of unfortunate life circumstances., and my doctor knows this. I’m a little creeped out about people reading all my message histories.
     To clarify, I was actually prescribed clorazapate (forgive the spelling) 7.5mg X 3 per day with my initial 20mg paxil back in 2001 – for General Anxiety Disorder, not panic disorder. Paxil treats the GAD anyways and it helped me tremenedously, to the point that I didn’t need the Clorazopate. I haven’t taken it for years as Paxil helped enough with my anxiety suffering – but Zoloft is not given the ok for GAD according to my reading. Your link for ZOloft is about Panic Disorder, I”m sure it’s great for that, and also SAD but It doesn’t say in any of the literature i have about GAD. However, I do not feel I need to start taking a Benzo again after reading more about them.  I don’t have any anxiety problems either, so in effect I’ve anwered my own question. I’m not the kind of person who is going to go out and buy drugs on the street for anxiety without telling my dr. I have anxiety., even though like I say…
     You’ve got to clarify what events I described look like “classic hypomania” or “awesome events” in your opinion. When I say Paxil made me feel good I should say that the first time I took paxil I was a little hyper the first 2 months, then the effect wore off and I haven’t had it since. Now, i would never call myself overly educated( even if I was a PhD.), but If that means I had hypomania or mania I wish I would have known then so I could get treatment!

Doroty answered 2 years ago

Eh, don’t sweat it.  I don’t know what she read – I didn’t do any track back before replying, I just remembered that you were starting Zoloft – but a lot of times I click on someone’s profile and read their last x number of posts to get some background before replying to a specific question.  Don’t feel creeped … consider it polite!  (Not getting into whether or not she’s got the right guy or her suggestions are warranted – that’s between you two  Smiley)

mania replied 2 years ago

That’s what I did. I try to have some background on posters I haven’t been writing to.

As to my armchair Dx, I was referring to this post you wrote.

I stand by my opinion.

paxil180 asked 3 years ago

Hi, I’m a depressed guy who has to take an SSRI everyday to feel ok. I’m ok with that. In fact my paxil and Zoloft sometimes make me feel so good I think I feel better than normal people who aren’t depressed and don’t take any crazymeds. Maybe. My question is about a Benzo – specifically Clorazapate.
  Will I suffer any long term effects from taking a daily 7.5mg dose of Clorazapate (or the equivilant 5mg dose of valium) to go along with my 150mg zoloft? I don’t ask a doctor because as most of you know these Benzos are for sale on practically every street corner in America, getting them isn’t a problem.

10 Answers
asery answered 2 years ago

It’s not unusual for a benzo to be added to an SSRI if you’re at the maximum tolerable dose of the SSRI and still having residual or situational anxiety.  Or (as in your case) while you’re giving the Zoloft time to take full effect.
 
But it’s not smart to keep things from your pdoc.  He needs full information to properly treat you, and if he’s doing that, you shouldn’t have to be buying things on street corners in addition to the neighborhood pharmacy!

mania answered 2 years ago

Yes, and no.
 
If you are on the depressed end of the scale, a benzo is the last drug you want to be tossing back, unless you have been Rx’d it for a comorbid anxiety condition. Which you obviously haven’t, or you’d be asking your doctor this, and wouldn’t be considering purchasing it on a street corner in HCM city.  (Although, if you had been Dx’d with panic, it says Here that Zoloft actually works just fine all by itself. )  
 
CNS depression, a really easy slide into addiction, an even harder fight out of said addiction, short half-lives, an ever increasing dose… the list goes on and on; is this something you want to take on if you don’t have to?
 
On to pharmacology.  They are both metabolized by your liver (Zoloft, also by kidneys).  Is your liver in good shape?  How about all of the nasty side effects and general “wrong” reasons for taking them in the first place?  See Here for Jerod’s lovely take on life, the universe, and everything you ever wanted to know about benzo use and abuse.  “In the bipolar world, there is a downside to long-term use of benzos. Their long-term use aggravates depression, especially bipolar depression, which is just one more reason why they are not a good class of drugs for control of mania in of themselves.” ( (c.) Jerod Poore)

Mag12 answered 2 years ago

“It’s amazing how much panic one honest man can spread among a multitude of hypocrites.”

– Thomas Sowell

“Nightmares, daymares, sneak-up-behind-you-and-kick-you-in-the-butt-mares… “

— Haunted_leaves, on manic/mixed episodes

They dont give me the charcoal, they tell me about Rasputin.

— Ragemaxis

panic-11 answered 2 years ago

Dude you must be confusing me with someone else’s posts on the board. My deal oficially is the Major Depressive Disorder. Frankly, it’s because of unfortunate life circumstances., and my doctor knows this. I’m a little creeped out about people reading all my message histories.
     To clarify, I was actually prescribed clorazapate (forgive the spelling) 7.5mg X 3 per day with my initial 20mg paxil back in 2001 – for General Anxiety Disorder, not panic disorder. Paxil treats the GAD anyways and it helped me tremenedously, to the point that I didn’t need the Clorazopate. I haven’t taken it for years as Paxil helped enough with my anxiety suffering – but Zoloft is not given the ok for GAD according to my reading. Your link for ZOloft is about Panic Disorder, I”m sure it’s great for that, and also SAD but It doesn’t say in any of the literature i have about GAD. However, I do not feel I need to start taking a Benzo again after reading more about them.  I don’t have any anxiety problems either, so in effect I’ve anwered my own question. I’m not the kind of person who is going to go out and buy drugs on the street for anxiety without telling my dr. I have anxiety., even though like I say…
     You’ve got to clarify what events I described look like “classic hypomania” or “awesome events” in your opinion. When I say Paxil made me feel good I should say that the first time I took paxil I was a little hyper the first 2 months, then the effect wore off and I haven’t had it since. Now, i would never call myself overly educated( even if I was a PhD.), but If that means I had hypomania or mania I wish I would have known then so I could get treatment!

Doroty answered 2 years ago

Eh, don’t sweat it.  I don’t know what she read – I didn’t do any track back before replying, I just remembered that you were starting Zoloft – but a lot of times I click on someone’s profile and read their last x number of posts to get some background before replying to a specific question.  Don’t feel creeped … consider it polite!  (Not getting into whether or not she’s got the right guy or her suggestions are warranted – that’s between you two  Smiley)

mania replied 2 years ago

That’s what I did. I try to have some background on posters I haven’t been writing to.

As to my armchair Dx, I was referring to this post you wrote.

I stand by my opinion.