Health QuestionsCategory: TreatmentsTegretol Start-up and Benzos
cache-monkey asked 3 years ago

[Also posted in the Bipolar Meds forum]
 
Hey all,  
 
So, I’m on Klonopin (a little Lithium) and just started Tegretol. I know that theoretically the Tegretol should increase the clearance of Klonopin (through the CYP-3A4 enzyme). Which implies raising the dose of K to get the same oomph, which I’m considering doing preemptively. (Klonopin tapering has been heinous for me in the past.)
 
But, Tegretol itself can increase GABA and is sometimes prescribed for benzo withdrawal. I think I’ve heard of people actually lowering their benzos after going on Tegretol, but I’d like to solicit any experiences.  So, for any people who’ve started Teg wile on a (non-Ativan) benzo for anxiety: Did you end up adjusting your benzo dose? Up, down?  
 
Thanks,  
cache-monkey

1 Answers
helgenen answered 3 years ago

Re: Tegretol Start-up and Benzos
Hi!
 
Sorry for the late reply. I’ve just tapered off Valium (took me five months!!!) so my head is not a well assembled machine at the moment Cheesy
 
I was on Tegretol when I started taking valium for anxiety, and was told to be careful because Tegretol could increase the effect of Valium. I was never told that the half-life would be affected, but that could have been a slip from my pdoc’s side.  
 
H.

cache-monkey asked 3 years ago

[Also posted in the Bipolar Meds forum]
 
Hey all,  
 
So, I’m on Klonopin (a little Lithium) and just started Tegretol. I know that theoretically the Tegretol should increase the clearance of Klonopin (through the CYP-3A4 enzyme). Which implies raising the dose of K to get the same oomph, which I’m considering doing preemptively. (Klonopin tapering has been heinous for me in the past.)
 
But, Tegretol itself can increase GABA and is sometimes prescribed for benzo withdrawal. I think I’ve heard of people actually lowering their benzos after going on Tegretol, but I’d like to solicit any experiences.  So, for any people who’ve started Teg wile on a (non-Ativan) benzo for anxiety: Did you end up adjusting your benzo dose? Up, down?  
 
Thanks,  
cache-monkey

1 Answers
helgenen answered 3 years ago

Re: Tegretol Start-up and Benzos
Hi!
 
Sorry for the late reply. I’ve just tapered off Valium (took me five months!!!) so my head is not a well assembled machine at the moment Cheesy
 
I was on Tegretol when I started taking valium for anxiety, and was told to be careful because Tegretol could increase the effect of Valium. I was never told that the half-life would be affected, but that could have been a slip from my pdoc’s side.  
 
H.

cache-monkey asked 3 years ago

[Also posted in the Bipolar Meds forum]
 
Hey all,  
 
So, I’m on Klonopin (a little Lithium) and just started Tegretol. I know that theoretically the Tegretol should increase the clearance of Klonopin (through the CYP-3A4 enzyme). Which implies raising the dose of K to get the same oomph, which I’m considering doing preemptively. (Klonopin tapering has been heinous for me in the past.)
 
But, Tegretol itself can increase GABA and is sometimes prescribed for benzo withdrawal. I think I’ve heard of people actually lowering their benzos after going on Tegretol, but I’d like to solicit any experiences.  So, for any people who’ve started Teg wile on a (non-Ativan) benzo for anxiety: Did you end up adjusting your benzo dose? Up, down?  
 
Thanks,  
cache-monkey

1 Answers
helgenen answered 3 years ago

Re: Tegretol Start-up and Benzos
Hi!
 
Sorry for the late reply. I’ve just tapered off Valium (took me five months!!!) so my head is not a well assembled machine at the moment Cheesy
 
I was on Tegretol when I started taking valium for anxiety, and was told to be careful because Tegretol could increase the effect of Valium. I was never told that the half-life would be affected, but that could have been a slip from my pdoc’s side.  
 
H.