Health QuestionsCategory: Treatmentstopamax and temporal lobe issues
maggiedelena asked 3 years ago

Short of having clear-cut, no-questions-about-it epilepsy, are there any kind of brain disorder indications of temporal lobe issues? I ask because I understand topamax can be good for them and I suspect I have them.  However my suspicions hinge primarily on some fairly serious paraphasia issues I have. What’s described on the temporal lobe page of this site elicted more of a  “well… kind of” reaction than an “ah ha! this is me!” reaction. Actually, most of the stuff seemed very applicable to me when I was a teenager, but less so as the years have gone by.  Almost as if I grew out of it.  
 
Anyway, pdoc thinks seizure activity is a possibility, as does nuerologist, but it’s really not clear cut.  And I haven’t had an MRI yet. And the MRI might not be conclusive anyway, right?
 
I’m just wondering if I should request a switch from depakote to topamax (the depakote is ok, but I’m taking a really low dose, and it’s helping with mixed states but not controlling them entirely. It’s also not entirely supressing cycling.  But if I go up on it, I get too depressed).
 
Diagnosis is BP NOS or I, depending on which pdoc you ask.  I have issues with mixed sates, anxiety, sleep (usually hypersomnia), substance abuse (no serious addictions, but I’m starting to worry about alcohol, and am addicted to nicorette) social anxiety, and some very occasional mild psychosis.  Current meds are depakote and risperdal. Don’t mind the risperdal – feel it helps with repetative thoughts and general mental clarity.  Only other meds I’ve tried were Zoloft (didn’t help, but was on it for a long time before going hypomanic) and Lamictal (unbearable mixed states, severe cognitive issues).  
 
 
 
 

2 Answers
gretl answered 3 years ago

Re: topamax and temporal lobe issues
Hmmm.  I think I gave you a link or two when you were asking about the aphasia stuff earlier.  Can’t come up with anything better than that right now.
 
Quote from maggiedelena on 24. Sep 2006 at 21:09:

Anyway, pdoc thinks seizure activity is a possibility, as does nuerologist, but it’s really not clear cut. And I haven’t had an MRI yet. And the MRI might not be conclusive anyway, right?

Nah, an MRI will just show if you have physical damage.  An EEG would show electrical activity, but doesn’t always catch what’s going on.
 
Quote:

I’m just wondering if I should request a switch from depakote to topamax

No.  I think you should wait and see what your tests show, and discuss a range of med options with the neuro and the pdoc.  There’s more than one med that hits temporal lobes, and Topamax on its own isn’t usually the best choice.  Especially for mixed states.  You may find the best results with a combination of AC’s.

rdpudge answered 3 years ago

Re: topamax and temporal lobe issues
Id like to hear more on this subject also….so any replies would be great!

maggiedelena asked 3 years ago

Short of having clear-cut, no-questions-about-it epilepsy, are there any kind of brain disorder indications of temporal lobe issues? I ask because I understand topamax can be good for them and I suspect I have them.  However my suspicions hinge primarily on some fairly serious paraphasia issues I have. What’s described on the temporal lobe page of this site elicted more of a  “well… kind of” reaction than an “ah ha! this is me!” reaction. Actually, most of the stuff seemed very applicable to me when I was a teenager, but less so as the years have gone by.  Almost as if I grew out of it.  
 
Anyway, pdoc thinks seizure activity is a possibility, as does nuerologist, but it’s really not clear cut.  And I haven’t had an MRI yet. And the MRI might not be conclusive anyway, right?
 
I’m just wondering if I should request a switch from depakote to topamax (the depakote is ok, but I’m taking a really low dose, and it’s helping with mixed states but not controlling them entirely. It’s also not entirely supressing cycling.  But if I go up on it, I get too depressed).
 
Diagnosis is BP NOS or I, depending on which pdoc you ask.  I have issues with mixed sates, anxiety, sleep (usually hypersomnia), substance abuse (no serious addictions, but I’m starting to worry about alcohol, and am addicted to nicorette) social anxiety, and some very occasional mild psychosis.  Current meds are depakote and risperdal. Don’t mind the risperdal – feel it helps with repetative thoughts and general mental clarity.  Only other meds I’ve tried were Zoloft (didn’t help, but was on it for a long time before going hypomanic) and Lamictal (unbearable mixed states, severe cognitive issues).  
 
 
 
 

2 Answers
gretl answered 3 years ago

Re: topamax and temporal lobe issues
Hmmm.  I think I gave you a link or two when you were asking about the aphasia stuff earlier.  Can’t come up with anything better than that right now.
 
Quote from maggiedelena on 24. Sep 2006 at 21:09:

Anyway, pdoc thinks seizure activity is a possibility, as does nuerologist, but it’s really not clear cut. And I haven’t had an MRI yet. And the MRI might not be conclusive anyway, right?

Nah, an MRI will just show if you have physical damage.  An EEG would show electrical activity, but doesn’t always catch what’s going on.
 
Quote:

I’m just wondering if I should request a switch from depakote to topamax

No.  I think you should wait and see what your tests show, and discuss a range of med options with the neuro and the pdoc.  There’s more than one med that hits temporal lobes, and Topamax on its own isn’t usually the best choice.  Especially for mixed states.  You may find the best results with a combination of AC’s.

rdpudge answered 3 years ago

Re: topamax and temporal lobe issues
Id like to hear more on this subject also….so any replies would be great!