Ultram (tramadol). Mouse is currently taking Ultram to deal with the pain of fibromyalgia. It is also the only antidepressant that works for her that she has recently tried. Unfortunately one shouldn’t take Ultram for longer than a year, because sometimes neuropathy may develop, and Mouse has been taking it for two years and she has developed neuropathy. You’d think that because Ultram binds to mc-opioid receptors and does weak inhibition of reuptake of norepinephrine and serotonin that there’d be studies up the wazoo for depression. But nooooooooo. Only now are studies in humans being undertaken as far as we can find. Ultram is also an opioid antagonist, but not as strong of one as Buprenex, so it has a nasty physical dependency. All the antagonism does is prevent you from getting high off of it. Normally Mouse goes batshit crazy with anything that messes with her serotonin, but she can tolerate Ultram, so it must not be hitting her serotonin receptors at all. Because it hits the opiate receptors, Ultram’s side effects are those common to opiates, mainly nausea, sedation, dizziness, constipation and sweating. As it is totally synthetic, it does have freaky rare side effects, it can make you go deaf or mimic the effects of flesh-eating bacteria. Like Buprenex the antidepressant hypothesis is an old one, opiates have been used to treat depression since forever. As Mouse is taking it for pain, she’s following the pain schedule, which is 50mg to 100mg every four to six hours, not to exceed 400 mg per day.